Table 2.

Mean values per group of the eigenvector centrality clusters, sub‐network functional connectivity, and subcortical volume and integrity

	Non‐diabetes controls	Type 1 diabetes	P‐valuea	Type 1 diabetes without proliferative retinopathy	Type 1 diabetes with proliferative retinopathy
Eigenvector centrality (*10−3)
Cluster all patients vs. controls	8.02 ± 0.19	7.83 ± 0.28	<0.001	7.77 ± 0.34*	7.90 ± 0.18*†
Cluster patients without retinopathy vs. controls (neg)	7.89 ± 0.15	7.77 ± 0.25	<0.001	7.70 ± 0.31*	7.85 ± 0.15†
Cluster patients without retinopathy vs. controls (pos)	8.02 ± 0.27	8.19 ± 0.27	0.002	8.30 ± 0.28*	8.09 ± 0.22†
Cluster patients without vs. with retinopathy (neg)	7.62 ± 0.25	7.58 ± 0.36	0.493	7.43 ± 0.42*	7.74 ± 0.18†
Cluster patients without vs. with retinopathy (pos)	8.20 ± 0.21	8.25 ± 0.24	0.289	8.35 ± 0.24*	8.14 ± 0.17†
Degree centrality
Cluster all patients vs. controls	1.07 ± 0.28	0.83 ± 0.25	<0.001	0.82 ± 0.27*	0.83 ± 0.24*
Cluster patients without retinopathy vs. controls	1.07 ± 0.31	0.82 ± 0.28	<0.001	0.76 ± 0.29*	0.88 ± 0.27*
Normalized Subcortical gray matter volume (mL)
Bilateral thalamus	10.5 ± 0.81	10.0 ± 0.83	0.026	10.2 ± 0.94	9.89 ± 0.69
Bilateral putamen	6.88 ± 0.70	6.44 ± 0.70	0.003	6.53 ± 0.67*	6.36 ± 0.71*
Bilateral caudate nucleus	4.78 ± 0.51	4.55 ± 0.55	0.201	4.54 ± 0.56	4.55 ± 0.55
Bilateral nucleus accumbens	0.75 ± 0.10	0.69 ± 0.13	0.011	0.72 ± 0.13	0.67 ± 0.13*

Values are presented as means with standard deviation.

^a P‐values are corrected for age, sex, systolic blood pressure and depressive symptoms.

*Significantly different from control participants.

^†Significantly different relative to type 1 diabetes patients without proliferative retinopathy.