Fig. 2.

Biodistribution of ‘free’/unchelated radionuclides. (A) Uptake of ‘free’ radionuclides in various tissue/organs, including tumours. The actual chemical form administered is denoted in brackets (including ¹¹¹In [22], ^99mTc [23], ¹⁸F [24], ^radioGa [25,26], ^radioI [27], ⁶⁴Cu [28,29], ⁸⁹Zr [30], ⁵²Mn [31]); (B) Representative mouse SPECT or PET images (maximum intensity projections) showing the biodistribution of ‘free’ ^99mTc, ⁶⁴Cu (reprinted with permission from Peng et al. [32], Copyright 2006 SNNMI), ⁸⁹Zr (reprinted with permission from Abou et al. [30], Copyright 2011 Elsevier) and ⁵²Mn (reprinted with permission from Graves et al. [31], Copyright 2015 ACS). (C) PET maximum intensity projection image of ⁶⁴CuCl₂ biodistribution in a prostate cancer patient (reprinted with permission from Piccardo et al. [29], Copyright 2018 SNNMI). High uptake in the liver and kidneys can be clearly seen, as well as in prostate cancer metastases in lymph nodes and bone (white arrows). Lg: lacrimal glands; Th+Sg: thyroid and salivary glands; St: stomach; Blad: bladder; Tu: tumour; H: heart; L: liver; K: kidney.