Fig. 6.

Small differences in the radiolabelling method can affect the biodistribution of liposomes. (A) Significantly higher EPR-mediated tumour and liver uptake and retention observed when using longer PEG chain lengths between the ⁸⁹Zr chelator (DFO) and the liposomal surface (shortest on top, longest at the bottom). (B) Significantly higher liver uptake observed over time for liposomes labelled on the surface with ¹¹¹In-DTPA (top row) compared to intraliposomally labelled liposomes using oxine and encapsulated DTPA (bottom row). EPR-mediated uptake in the infected tissue was not significantly different. Figures adapted with permission from (A) Seo et al. [81] and (B) Van der Geest et al. [60], Copyright 2015 Elsevier.