Table 4.

Heritability estimates of left and right hippocampal subfield volumes with 95% confidence intervals (sample size N = 465)

	No volume adjustment (only adjusted for sex and age)		Total brain volume adjustment		ipsilateral hippocampal volume adjustment		ipsilateral hippocampal and total brain volume adjustment
Region	H 2 (%)	95% confidence interval	H 2 (%)	95% confidence interval	H 2 (%)	95% confidence interval	H 2 (%)	95% confidence interval
Left CA1	73**	55–83	56**	33–72	39**	21–55	39	21–55
Right CA1	70**	50–83	54**	29–71	59*	42–72	59*	42–72
Left CA2CA3	38*	18–58	41**	21–59	53*	35–67	52*	34–67
Right CA2CA3	70**	51–82	68**	51–80	67*	52–78	66*	50–78
Left CA4DG	77**	58–87	65**	41–81	57**	38–73	57**	37–73
Right CA4DG	80**	65–88	72**	54–83	65**	50–76	65**	50–76
Left SRLM	64**	42–78	53**	30–70	47*	30–62	40*	22–56
Right SRLM	74**	56–84	64**	43–78	59**	42–72	55**	38–69
Left subiculum	50*	16–77	63**	26–75	60*	20–72	57**	22–71
Right subiculum	85**	68–90	76**	62–84	82**	71–88	78**	65–86
Left hippocampus	80**	66–88	65**	43–80
Right hippocampus	81**	66–89	63**	41–78
Total brain	92**	75–95

Significant heritability P values are represented by * indicates P < 0.05, and ** indicates P < 0.001 when ACE model is compared to CE model. Heritability estimates highlighted in yellow are not significant, but show a trend toward significance.