Figure 2.

Summary of the analytic steps followed for the MDMR analyses. Step 1: Building individual whole‐brain (1A) and reduced (1B) structural connectivity profiles. Step 2: Calculation of the distance matrix among individuals in the whole‐brain and reduced structural connectivity profiles. Step 3: Multivariate distance matrix regression (MDMR) analysis setting as dependent variable the computed distance matrices (whole‐brain and reduced) and as independent variables brain volume, age, and the six cognitive domains [fluid reasoning (Gf), crystallized ability (Gc), and spatial ability (Gv), along with working memory capacity (WMC), attention control (ATT), and processing speed (PS)]. [Color figure can be viewed at http://wileyonlinelibrary.com]