Table 4.
Fitting parameters for deep gray matter structures volume versus age within each cohort
| Structure | Cohort | Best fit model | Parameter (S.E.) | |||||
|---|---|---|---|---|---|---|---|---|
| Intercepta | Age (linear) | Age (exponential) | Sex | Age2 | Interaction (age * sex or age2 * sex) | |||
| Thalamus | Cross‐Sectional | Poisson | 13.44 (0.30) | 0.48 (0.04) | 0.05 (<0.01) | −1.61 (0.14) | – | n.s. |
| Long.—Young | None | – | – | – | – | – | – | |
| Long.—Aging | Linear | 17.51 (1.20) | −0.07 (0.02) | – | n.s. | – | n.s. | |
| Caudate | Cross‐Sectional | Poisson | 7.22 (0.15) | 0.23 (0.03) | 0.07 (0.01) | −0.66 (0.1) | – | n.s. |
| Long.—Young | None | – | – | – | – | – | – | |
| Long.—Aging | None | – | – | – | – | – | – | |
| Putamen | Cross‐Sectional | Poisson | 10.47 (0.15) | 0.65 (0.04) | 0.08 (<0.01) | −1.12 (0.11) | – | n.s. |
| Long.—Young | Quadratic | 11.51 (0.37) | 0.11 (0.04) | – | −1.1 (0.27) | −0.005 (0.001) | n.s. | |
| Long.—Aging | Linear | 12.18 (0.85) | −0.04 (0.01) | – | −1.51 (0.29) | – | n.s. | |
| Globus pallidus | Cross‐Sectional | Poisson | 3.3 (0.06) | 0.17 (0.01) | 0.08 (0.01) | −0.41 (0.04) | – | n.s. |
| Long.—Young | Quadratic | 3.19 (0.18) | 0.07 (0.02) | – | −0.52 (0.09) | −0.003 (0.001) | n.s. | |
| Long.—Aging | None | – | – | – | – | – | – | |
| Hippocampus | Cross‐Sectional | Quadratic | 9.1 (0.13) | 0.03 (0.01) | – | −0.69 (0.08) | −0.001 (<0.01) | n.s. |
| Long.—Young | Quadratic | 8.17 (0.22) | −0.02 (0.01) | – | −0.86 (0.17) | −0.003 (0.001) | n.s. | |
| Long.—Aging | Linear | 12.17 (0.6) | −0.07 (0.01) | – | −0.69 (0.17) | – | n.s. | |
| Amygdala | Cross‐Sectional | Poisson | 2.85 (0.08) | 0.08 (0.01) | 0.04 (<0.01) | −0.34 (0.03) | – | n.s. |
| Long.—Young | Quadratic | 2.57 (0.11) | 0.06 (0.01) | – | −0.37 (0.07) | −0.002 (<0.01) | n.s. | |
| Long.—Aging | Linear | 4.25 (0.32) | −0.02 (0) | – | −0.5 (0.5) | – | n.s. | |
| Nucleus accumbens | Cross‐Sectional | Linear | 1.42 (0.02) | −0.01 (0) | – | −0.13 (0.02) | – | n.s. |
| Long.—Young | Linear | 1.3 (0.05) | −0.01 (0) | – | −0.16 (0.04) | – | n.s. | |
| Long.—Aging | Linear | 1.41 (0.12) | −0.01 (0) | – | −0.17 (0.03) | – | n.s. | |
a
Intercept is the extrapolated volume at age zero.
– = not applicable; n.s. = non‐significant.