Table 2.
Regions activated by a contrast of all anxiety levels (irrespective of level) versus neutral pictures
| Brain region | Brodmann areas (BA) | Spider phobics: anxiety > neutral | Control group: anxiety > neutral | Spider phobics > control group (anxiety > neutral) | |
|---|---|---|---|---|---|
| Cluster threshold | 186 voxels | 45 voxels | 177 voxels | ||
| x/y/z (no of voxels) | x/y/z (no of voxels) | x/y/z (no of voxels) | |||
| Midbrain | |||||
| Brainstem and superior colliculi | L | −8/−27/−3 (95) | −12/−23/−3 (14) | −7/−19/−9 (65) | |
| R | 8/−25/−3 (83) | 14/−26/−3 (7) | 8/−20/−9 (45) | ||
| Visual areas | |||||
| Visual cortex | L | 17, 18, 19, 37 | −45/−71/−7 (804) | −52/−58/7 174) | −21/−87/−5 (312) |
| R | 17, 18, 19, 37 | 30/−75/−12 (678) | 51/−63/4 (59) | 15/−77/−5 (271) | |
| Subcortical areas | |||||
| Thalamus | L | −10/−22/15 (152) | — | −9/−7/12 (60) | |
| R | 6/−11/7 (43) | — | 3/−12/13 (42) | ||
| Striatum | L | −7/10/10 (70) | — | −9/10/12 (61) | |
| R | 8/6/9 (37) | — | 13/13/15 (33) | ||
| Amygdala | L | — | — | — | |
| R | — | — | — | ||
| Medial/temporal areas | |||||
| Anterior insula | L | 13 | −34/16/6 (71) | — | — |
| R | 13 | 39/22/10 (116) | — | — | |
| Mid insula | L | 13 | −34/8/6 (82) | — | — |
| R | 13 | 38/7/0 (20) | — | — | |
| Dorsal anterior cingulate | L | 24, 32 | −9/25/31 (134) | — | — |
| R | 24, 32 | 5/25/32 (113) | — | — | |
| Prefrontal areas | |||||
| Ventrolateral prefrontal cortex | L | 44, 45, 47 | −50/14/1 (47) | — | — |
| R | 44, 45, 47 | 51/22/7 (51) | — | — | |
| Orbitofrontal cortex | L | 10, 11 | −22/43/−3 (114) | — | — |
| R | 10, 11 | 36/59/12 (72) | — | 32/51/12 (115) | |
| Dorsolateral prefrontal cortex | L | 8, 9, 46 | −45/22/28 (124) | — | −50/14/36 (121) |
| R | 8, 9, 46 | 40/22/31 (168) | — | 40/29/31 (111) | |
| Posterior areas | |||||
| Posterior cingulate | L | 23,29 | −7/−35/22 (200) | — | — |
| R | 23,29 | 3/−38/21 (123) | — | — | |
L, left hemisphere; R, right hemisphere.
Talairach coordinates of the most significant voxel and the number of significantly activated functional voxels (3 × 3 × 3 mm3) are reported. Results from whole‐brain random‐effects GLM, P < 0.05 at cluster level, the applied cluster thresholds applied are reported.