Table 4.
Optimum feature set (neuroanatomical decision function) of SVM model achieving the highest accuracy of classification for fep subjects experiencing auditory hallucination from HC
| No. | ROI_I_name | ROI_J_name | T stat [LOOGC] Mean | FEP‐AH (N = 27), Mean (SD) | FEP‐NAH (N = 24), Mean (SD) | HC (N = 96), Mean (SD) |
|---|---|---|---|---|---|---|
| CSA‐ISC: FEP‐AH vs. HC | ||||||
| 1 | Lt. short insular gyrus | Lt. inferior frontal sulcus | −4.714 | 0.19 (0.28) | 0.25 (0.29) | 0.5 (0.35) |
| 2 | Lt. inferior frontal sulcus | Lt. parieto‐occipital sulcus (visuospatial processing; V6/V6Av/V6Ad) | −4.619 | 0.17 (0.25) | 0.49 (0.36) | 0.45 (0.36) |
| 3 | Lt. PCC | Lt. pars orbitalis | −4.591 | 0.20 (0.29) | 0.37 (0.39) | 0.51 (0.37) |
| 4 | Lt. precuneus | Lt. temporal pole | 4.389 | 0.72 (0.31) | 0.57 (0.33) | 0.42 (0.37) |
| 5 | Rt. Heschl's gyrus | Lt. ACC | −4.156 | 0.25 (0.27) | 0.42 (0.35) | 0.51 (0.36) |
| 6 | Rt. parahippocampal gyrus | Lt. inferior frontal sulcus | −4.123 | 0.22 (0.29) | 0.43 (0.39) | 0.50 (0.38) |
| 7 | Lt. postcentral gyrus | Lt. inferior precentral sulcus | 4.123 | 0.71 (0.32) | 0.48 (0.39) | 0.42 (0.35) |
| 8 | Rt. frontal pole | Lt. pars triangularis | −4.069 | 0.26 (0.28) | 0.44 (0.37) | 0.53 (0.38) |
| 9 | Lt. parieto‐occipital sulcus (visuospatial processing; V6/V6Av/V6Ad) | Lt. transverse temporal sulcus | −4.015 | 0.21 (0.25) | 0.42 (0.35) | 0.46 (0.38) |
| 10 | Rt. subcallosal gyrus | Lt. lateral orbital sulcus | −4.012 | 0.27 (0.31) | 0.46 (0.40) | 0.55 (0.38) |
| 11 | Rt. lateral orbital sulcus | Lt. marginalis branch of the cingulate sulcus | 3.985 | 0.72 (0.29) | 0.45 (0.44) | 0.45 (0.39) |
| 12 | Rt. frontal pole | Rt. superior parietal lobule | 3.922 | 0.68 (0.28) | 0.55 (0.36) | 0.43 (0.36) |
| 13 | Rt. PCC | Rt. cuneus | −3.906 | 0.25 (0.28) | 0.39 (0.39) | 0.50 (0.36) |
| 14 | Lt. fronto‐marginal gyrus/sulcus | Lt. lingual gyrus | 3.872 | 0.72 (0.27) | 0.46 (0.36) | 0.47 (0.36) |
| 15 | Rt. planum polare | Lt. superior precentral sulcus | 3.834 | 0.69 (0.30) | 0.48 (0.39) | 0.43 (0.34) |
| 16 | Rt. long insular gyrus/central sulcus | Lt. calcarine sulcus | −3.813 | 0.23(0.27) | 0.29 (0.35) | 0.48 (0.38) |
| 17 | Lt. parieto‐occipital sulcus (visuospatial processing; V6/V6Av/V6Ad) | Lt. inferior precentral sulcus | −3.803 | 0.26 (0.28) | 0.43 (0.38) | 0.51 (0.37) |
| CT‐ ISC: FEP‐AH vs. HC | ||||||
| 1 | Rt. planum temporale | Rt. postcentral sulcus | −4.915 | 0.26 (0.27) | 0.45 (0.32) | 0.58 (0.36) |
| 2 | Lt. angular gyrus | Rt. superior frontal sulcus | −4.833 | 0.17 (0.20) | 0.49 (0.39) | 0.43 (0.37) |
| 3 | Lt. inferior occipital gyrus/sulcus | Lt. inferior precentral sulcus | −4.606 | 0.14 (0.25) | 0.40 (0.37) | 0.43 (0.39) |
| 4 | Rt. superior frontal sulcus | Lt. precentral gyrus | −4.445 | 0.19 (0.26) | 0.40 (0.39) | 0.46 (0.35) |
| 5 | Lt. angular gyrus | Lt. inferior precentral sulcus | −4.303 | 0.20 (0.25) | 0.49 (0.36) | 0.46 (0.36) |
| 6 | Lt. occipital pole | Lt. suborbital sulcus | 4.277 | 0.70 (0.36) | 0.32 (0.34) | 0.37 (0.34) |
| 7 | Rt. central sulcus | Rt. superior precentral sulcus | −4.269 | 0.20 (0.25) | 0.41 (0.42) | 0.46 (0.37) |
| 8 | Rt. superior precentral sulcus | Lt. precentral gyrus | −4.258 | 0.26 (0.31) | 0.26 (0.32) | 0.56 (0.37) |
| 9 | Rt. inferior temporal sulcus | Lt. anterior occipital sulcus (hOc5, motion‐sensitive area (V5/MT+)) | −4.037 | 0.23 (0.28) | 0.57 (0.34) | 0.50 (0.36) |
| 10 | Rt. superior precentral sulcus | Lt. supramarginal gyrus | −4.027 | 0.22 (0.23) | 0.43 (0.36) | 0.45 (0.36) |
| 11 | Lt. superior occipital gyrus | Lt. IPS | 4.01 | 0.71 (0.31) | 0.45 (0.31) | 0.43 (0.36) |
| 12 | Rt. pMCC | Rt. inferior precentral sulcus | 3.918 | 0.72 (0.32) | 0.52 (0.35) | 0.44 (0.38) |
| 13 | Rt. inferior precentral sulcus | Rt. subobital sulcus | 3.917 | 0.71 (0.30) | 0.49 (0.41) | 0.44 (0.36) |
| 14 | Lt. Heschl's gyrus | Lt. occipital pole | −3.913 | 0.25 (0.24) | 0.29 (0.30) | 0.48 (0.37) |
| 15 | Rt. vertical ramus of the anterior segment of the lateral sulcus | Rt. anterior transverse collateral sulcus (building related area) | −3.798 | 0.26 (0.28) | 0.52 (0.41) | 0.51 (0.37) |
| 16 | Rt. superior parietal lobule | Rt. lateral superior temporal gyrus | 3.794 | 0.68 (0.31) | 0.56 (0.38) | 0.42 (0.35) |
| 17 | Rt. anterior transverse collateral sulcus (building related area) | Lt. superior frontal sulcus | −3.783 | 0.22 (0.32) | 0.33 (0.36) | 0.50 (0.38) |
| 18 | Rt. superior occipital gyrus | Rt. lateral orbital sulcus | −3.776 | 0.24 (0.28) | 0.38 (0.35) | 0.49 (0.37) |
| 19 | Lt. Heschl's gyrus | Lt. middle temporal gyrus | −3.765 | 0.24 (0.29) | 0.42 (0.37) | 0.49 (0.36) |
Abbreviations: ACC, anterior cingulate cortex; FEP‐AH, first episode psychosis with auditory hallucination; FEP‐NAH, first episode psychosis without auditory hallucination; HC, healthy control; LOOGC, leave‐one‐out group‐comparison; L, left; PCC, posterior cingulate cortex; R, Right.