Table 5.
Optimum feature set (neuroanatomical decision function) of SVM model achieving the highest accuracy of classification for FEP subjects without auditory hallucination from HC
| No. | ROI_I_name | ROI_J_name | T stat [LOOGC] Mean | FEP‐AH (N = 27), Mean (SD) | FEP‐NAH (N = 24), Mean (SD) | HC (N = 96), Mean (SD) |
|---|---|---|---|---|---|---|
| CSA‐ISC: FEP‐NAH vs. HC | ||||||
| 1 | Rt. PCC | Left posterior transverse collateral sulcus (ptCoS: hV4/VO1 boundary) | −4.548 | 0.37 (0.38) | 0.17 (0.26) | 0.46 (0.38) |
| 2 | Lt. inferior frontal sulcus | Lt. subparietal sulcus | −4.485 | 0.31 (0.36) | 0.22 (0.27) | 0.52 (0.36) |
| 3 | Rt. inferior occipital gyrus/sulcus | Lt. transverse occipital sulcus (scene‐selective TOS) | −4.237 | 0.48 (0.39) | 0.19 (0.31) | 0.51 (0.36) |
| 4 | Lt. transverse occipital sulcus (scene‐selective TOS) | Lt. pericallosal sulcus | −4.055 | 0.44 (0.37) | 0.16 (0.28) | 0.43 (0.37) |
| 5 | Rt. Sulcus intermedius primus | Lt. ACC | −4.035 | 0.30 (0.37) | 0.20 (0.27) | 0.47 (0.36) |
| 6 | Rt. posterior transverse collateral sulcus (ptCoS: hV4/VO1 boundary) | Lt. Sulcus intermedius primus | 3.989 | 0.40 (0.37) | 0.72 (0.33) | 0.41 (0.37) |
| 7 | Rt. inferior occipital gyrus/sulcus | Lt. superior frontal sulcus | −3.977 | 0.47 (0.37) | 0.20 (0.26) | 0.46 (0.36) |
| 8 | Rt. Sulcus intermedius primus | Rt. Lateral orbital sulcus | −3.95 | 0.44 (0.42) | 0.23 (0.33) | 0.54 (0.37) |
| 9 | Rt. Inferior segment of the circular sulcus | Rt. superior precentral sulcus | 3.946 | 0.46 (0.33) | 0.69 (0.29) | 0.42 (0.34) |
| 10 | Rt. lateral occipito‐temporal sulcus (recognizing face) | Rt. postcentral sulcus | 3.945 | 0.51 (0.35) | 0.72 (0.30) | 0.43 (0.37) |
| 11 | Rt. anterior transverse collateral sulcus (building related area) | Lt. lateral occipito‐temporal sulcus (visual word form area) | −3.848 | 0.43 (0.36) | 0.18 (0.26) | 0.45 (0.41) |
| 12 | Rt. Long insular gyrus and central sulcus | Lt. transverse occipital sulcus (scene‐selective TOS) | −3.838 | 0.36 (0.37) | 0.24 (0.21) | 0.46 (0.35) |
| 13 | Rt. dPCC | Rt. precentral gyrus | −3.775 | 0.45 (0.38) | 0.23 (0.29) | 0.50 (0.38) |
| 14 | Rt. angular gyrus | Lt. transverse frontopolar gyrus/sulcus | −3.769 | 0.45 (0.37) | 0.24 (0.32) | 0.52 (0.38) |
| CT‐ISC: FEP‐NAH vs. HC | ||||||
| 1 | Rt. medial occipito‐temporal sulcus | Rt. superior precentral sulcus | −5.525 | 0.44 (0.39) | 0.15 (0.23) | 0.49 (0.38) |
| 2 | Rt. temporal pole | Lt. transverse frontopolar gyri and sulci | −5.409 | 0.49 (0.38) | 0.18 (0.26) | 0.53 (0.37) |
| 3 | Rt. medial orbital sulcus | Lt. precentral gyrus | −5.396 | 0.32 (0.35) | 0.14 (0.20) | 0.44 (0.38) |
| 4 | Rt. anterior transverse collateral sulcus (building related area) | Lt. precentral gyrus | −4.786 | 0.41 (0.40) | 0.15 (0.23) | 0.43 (0.35) |
| 5 | Lt. cuneus | Lt. inferior temporal gyrus | 4.58 | 0.55 (0.38) | 0.70 (0.28) | 0.39 (0.36) |
| 6 | Rt. fronto‐marginal gyrus/sulcus | Lt. precentral gyrus | −4.528 | 0.36 (0.42) | 0.19 (0.22) | 0.45 (0.35) |
| 7 | Rt. precuneus | Rt. superior precentral sulcus | −4.511 | 0.36 (0.37) | 0.20 (0.27) | 0.51 (0.38) |
| 8 | Lt. parahippocampal gyrus | Lt. suborbital sulcus | −4.468 | 0.45 (0.38) | 0.19 (0.23) | 0.45 (0.36) |
| 9 | Rt. fronto‐marginal gyrus/sulcus | Lt. superior segment of the circular sulcus | −4.327 | 0.42 (0.36) | 0.22 (0.25) | 0.49 (0.35) |
| 10 | Rt. pars orbitalis | Rt. pars triangularis | 4.231 | 0.60 (0.30) | 0.73 (0.29) | 0.44(0.32) |
| 11 | Rt. Long insular gyrus and central sulcus | Rt. Precuneus | −4.214 | 0.50 (0.37) | 0.20 (0.25) | 0.47 (0.37) |
| 12 | Lt. inferior frontal sulcus | Lt. superior precentral sulcus | −4.213 | 0.32 (0.34) | 0.23 (0.27) | 0.51 (0.36) |
| 13 | Rt. angular gyrus | Rt. inferior segment of the circular sulcus | −4.165 | 0.40 (0.35) | 0.19 (0.26) | 0.46 (0.34) |
| 14 | Rt. planum temporale | Rt. medial occipito‐temporal sulcus | −4.136 | 0.35 (0.39) | 0.17 (0.24) | 0.42 (0.37) |
| 15 |
Lt. posterior transverse collateral sulcus (ptCoS: hV4/VO1 boundary) |
Lt. medial occipito‐temporal sulcus | −4.111 | 0.37 (0.35) | 0.23 (0.24) | 0.49 (0.37) |
| 16 | Rt. inferior temporal gyrus | Rt. superior precentral sulcus | −4.048 | 0.44 (0.44) | 0.20 (0.28) | 0.48 (0.38) |
| 17 | Lt. pars orbitalis | Lt. parahippocampal gyrus | −4.044 | 0.51 (0.37) | 0.21 (0.25) | 0.47 (0.36) |
| 18 | Rt. medial occipito‐temporal sulcus | Rt. medial orbital sulcus | −4.025 | 0.40 (0.38) | 0.21 (0.28) | 0.48 (0.35) |
| 19 | Lt. ACC | Lt. parahippocampal gyrus | −3.973 | 0.40 (0.36) | 0.22 (0.28) | 0.49 (0.37) |
| 20 | Lt. horizontal ramus of the anterior segment of the lateral sulcus | Lt. inferior frontal sulcus | −3.846 | 0.53 (0.38) | 0.23 (0.22) | 0.45 (0.34) |
| 21 | Rt. superior precentral sulcus | Lt. precentral gyrus | −3.828 | 0.26 (0.31) | 0.26 (0.32) | 0.56 (0.37) |
| 22 | Rt. Superior precentral sulcus | Lt. superior parietal lobule | −3.768 | 0.29 (0.31) | 0.23 (0.26) | 0.48 (0.37) |
| 23 | Rt. ACC | Lt. ACC | 3.755 | 0.56 (0.33) | 0.78 (0.26) | 0.54 (0.33) |
Abbreviations: ACC, anterior cingulate cortex; FEP‐AH, first episode psychosis with auditory hallucination; FEP‐NAH, first episode psychosis without auditory hallucination; HC, healthy control; LOOGC, leave‐one‐out group‐comparison; L, left; R, Right.