Figure 2.

Brain areas showing significant linear or non‐linear age‐related changes in regional glucose metabolism. Top. Significant changes were found in dorsomedial prefrontal/anterior cingulate cortices (DMPFC/ACC), thalamic (thal) and hippocampal (hipp) regions bilaterally as well as in the cerebellum (lobules VIIIb and IX). R, right; L, left. Images are thresholded at P < 0.05 corrected for multiple comparisons over the entire brain volume (Family Wise Error, FWE). The color scale on the right of the figure represents the F‐statistic of the significant voxels. Bottom. Regression plots illustrating the evolution of the metabolic activity with age for these brain areas.