Table 1.

Direct effects of LSD on network‐level sample entropy (mixed‐effects model)

Network		Stats
N	Description	T Drug	P Drug	T Drug × state:L	P Drug × state:L	T Drug × state:Q	P Drug × state:Q
1	Secondary Visual	4.698	<0.001***	−0.536	0.594	1.647	0.103
2	Primary Visual	6.019	<0.001***	−0.034	0.973	1.567	0.121
3	Superior Sensorimotor	6.209	<0.001***	0.050	0.961	0.387	0.699
4	Inferior Sensorimotor	1.238	0.219	0.111	0.912	0.124	0.902
5	Superior Parietal	4.961	<0.001***	−0.206	0.837	0.486	0.628
6	Posterior Sensorimotor	5.971	<0.001***	−0.320	0.750	0.187	0.852
7	Posterior Salience	1.651	0.102	0.304	0.762	−0.097	0.923
8	Anterior Salience	4.020	<0.001***	0.582	0.562	0.017	0.986
9	Anterior MTL	−0.710	0.479	0.258	0.797	0.169	0.866
10	Orbitofrontal	0.651	0.517	−0.114	0.910	0.387	0.700
11	Precuneus	6.068	<0.001***	0.556	0.580	−0.119	0.905
12	Inferior Frontoparietal	6.401	<0.001***	−0.264	0.792	0.786	0.434
13	Superior Frontoparietal	5.171	<0.001***	0.288	0.774	0.638	0.525
14	Auditory	0.511	0.610	0.139	0.889	0.020	0.984
15	Hippocampal	2.531	0.013*	0.914	0.363	0.088	0.930
16	Default Mode	3.594	0.001**	0.643	0.522	0.258	0.797
17	Frontotemporal	1.560	0.122	0.217	0.828	0.271	0.787

Global (cortical) effect of LSD on brain entropy: T = 4.34 (P < 0.001).

Caption:

Networks showing significant effects of the drug are highlighted in bold.

T = t‐value; P = P‐value;

Drug × state:L = drug‐by‐state interaction: linear term.

Drug × state:Q = drug‐by‐state interaction: quadratic term.

***P<0.001

**P<0.01

*P<0.05