Table 1.
List of 37 studies included in the ALE analysis
| Paper | Imaging method | Statistical comparison | Stat. threshold | n of included clusters |
|---|---|---|---|---|
| Functional studies FMS vs controls | ||||
| Brown et al. Eur. J. Neurosci. 2014;39:663–672. | EEG | 16 FMS, 15 HC, 16 OA | corr. 0.05 | 14 |
| Burgmer et al. Psychosom. Med. 2011;73:751–759. | fMRI | 12 FMS, 14 HC | corr. 0.05 | 2 |
| Burgmer et al. Eur. J. Pain 2012;16:636–647. | fMRI | 17 FMS, 17 HC | corr. 0.05 | 3 |
| Glass et al. J. Pain 2011;12:1219–1229. | fMRI | 18 FMS, 14 HC | corr. 0.05 | 10 |
| Gracely et al. Arthritis Rheum. 2002;46:1333–1343. | fMRI | 16 FMS, 16 HC | corr. 0.05 | 14 |
| Guedj et al. Eur. J. Nucl. Med. Mol. Imaging 2007a;34:130–134. | SPECT | 18 FMS, 10 HC | corr. 0.05 | 18 |
| Harris et al. J. Neurosci. 2007;27:10000–10006. | PET | 17 FMS, 17 HC | corr. 0.05 | 4 |
| Jensen et al. Pain 2009;144:95–100. | fMRI | 16 FMS, 16 HC | uncorr. 0.005 | 2 |
| Jensen et al. Arthritis Rheum. 2013;65:3293–3303.a | fMRI | 26 FMS, 13 HC | corr. 0.05 | 1 |
| Kim et al. PLoS One 2013;8:e74099. | fMRI | 21 FMS, 11 HC | corr. 0.05 | 8 |
| Loggia et al. Arthritis Rheumatol. 2014;66:203–212. | fMRI | 31 FMS, 14 HC | corr. 0.05 | 25 |
| Lopez‐Sola et al. Arthritis Rheumatol. 2014;66:3200–3209. | fMRI | 35 FMS, 25 HC | corr. 0.05 | 8 |
| Maestu et al. Clin. Neurophysiol. 2013;124:752–760. | MEG | 9 FMS, 9 HC | corr. 0.01 | 9 |
| Martinsen et al. PLoS One 2014;9:e108637. | fMRI | 23 FMS, 28 HC | uncorr. 0.001 | 7 |
| Pujol et al. PLoS One 2009;4:e5224. | fMRI | 9 FMS, 9 HC | corr. 0.05 | 14 |
| Usui et al. Arthritis Res. Ther. 2010;12:R64. | SPECT | 29 FMS, 10 HC | corr. 0.05 | 10 |
| Wik et al. Neuroreport 2003;14:619–621. | PET | 8 FMS, 8 HC | corr. | 3 |
| Wood et al. J. Pain 2007;8:51–58. | PET | 6 FMS, 8 HC | uncorr. 0.01 | 14 |
| Functional studies within FMS | ||||
| Boyer et al. Neurology 2014;82:1231–1238. | PET | 16 FMS, 13 FMS | uncorr. 0.001 | 1 |
| Guedj et al. Eur. J. Nucl. Med. Mol. Imaging 2007c;34:2115–2119. | SPECT | 11 FMS, 6 FMS | uncorr. 0.001 | 3 |
| Harris et al. Neuroimage 2009;47:1077–1085. | PET | 10 FMS, 10 FMS | corr. 0.05 | 2 |
| Jensen et al. Pain 2012;153:1495–1503. | fMRI | 19 FMS, 15 FMS | corr. 0.05 | 1 |
| Jensen et al. J. Pain 2014;15:1328–1337. | fMRI | 21 FMS, 16 FMS | corr. 0.05 | 1 |
| Schmidt‐Wilcke et al. Pain Med. 2014;15:1346–1358. | fMRI | 8 FMS, 8 FMS | corr. 0.05 | 1 |
| Wik et al. Eur. J. Pain 1999;3:7–12. | PET | 8 FMS (pre/post) | uncorr. 0.00 | 10 |
| Structural studies | ||||
| Ceko et al. Neuroimage Clin. 2013;3:249–260. | VBM | 27 FMS, 26 HC | corr. 0.05 | 9 |
| Fallon et al. Neuroimage Clin. 2013;3:163–170. | VBM | 16 FMS, 15 HC | corr. 0.05 | 4 |
| Hsu et al. Pain 2009;143:262–267. | VBM | 29 FMS, 29 HC | corr. 0.05 | 0 |
| Jensen et al. Arthritis Rheum. 2013;65:3293–3303.a | cortical thickness | 26 FMS, 13 HC | corr. 0.05 | 7 |
| Kim et al. Arthritis Rheumatol. 2014;66:3190–3199. | DTI | 19 FMS, 18 HC | corr. 0.05 | 1 |
| Schmidt‐Wilcke et al. Pain 2007;132 Suppl 1:S109–S116. | VBM | 20 FMS, 22 HC | corr. 0.05 | 3 |
| Connectivity studies | ||||
| Flodin et al. Brain Connect. 2014;4:587–594. | rsMRI | 16 FMS, 22 HC | corr. 0.05 | 6 |
| Harris et al. Anesthesiology 2013;119:1453–1464. | rsMRI | 14 FMS (pre/post) | uncorr. 0.05 | 6 |
| Ichesco et al. J. Pain 2014;15:815–826.e1. | rsMRI | 18 FMS, 18 HC | corr. 0.05 | 8 |
| Jensen et al. Mol. Pain 2012;8:32–8069‐8‐32. | fMRI | 28 FMS, 14 HC | corr. 0.05 | 4 |
| Napadow et al. Arthritis Rheum. 2010;62:2545–2555. | rsMRI | 18 FMS, 18 HC | corr. 0.05 | 5 |
| Napadow et al. Arthritis Rheum. 2012;64:2398–2403. | fMRI | 17 FMS (pre/post) | corr. 0.05 | 2 |
| Pujol et al. Pain 2014;155:1492–1503. | rsMRI | 40 FMS, 36 HC | corr. 0.05 | 34 |
a
aStudy of Jensen included functional and structural analyses.
SPECT = Single Photon Emission Computed Tomography, PET = Positron Emission Tomography, VBM = Voxel‐based morphometry, DTI = diffusion tensor imaging, fMRI = functional Magnetic Resonance Imaging, rsMRI = resting‐state MRI, EEG = Electroencephalography, MEG = Magnetoencephalography, sr = seed regression, ICN = intrinsic connectivity network.