FIGURE 3.

Anticancer drug response with mutational contexts. Four anticancer drugs (5-Fu [A], cisplatin [B], paclitaxel [C], and gemcitabine [D]) were used to estimate drug response of the established pancreatic cancer cell lines. SNU-2564, SNU-2570, and SNU-2608 cell lines were the most resistant group for the anticancer agents. SNU-2608 was the most resistant cell line for all anticancer drugs tested in this study. E, Mutational status of 20 genes that have been reported to be involved in PA was screened with regard to the calculated response of 5 anticancer drugs.