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. 2019 Jul 22;44(23):1613–1622. doi: 10.1097/BRS.0000000000003150

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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(A) Fraction of proliferating bovine IVD (bIVD) cells significantly increased between day 0 (T0: 0.9% ± 0.1%) and day 5 after MSC homing (3.8% ± 0.7%, P = 0.04) (n = 4 bovine tails, hMSC#1). (B) MSC homing induced a significantly higher proliferative response at day 5(ctrl: 2.5% ± 1.6%, treated: 4.3% ± 0.9%, P = 0.013) (n = 7 bovine tails, 2 MSC donors). (C) Individual fold change (relative to donor corresponding ctrl) of data points represented in Fig. 5B. IVD indicates intervertebral disc; MSCs, mesenchymal stem cells.