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. 2019 Nov 20;39(47):9277–9293. doi: 10.1523/JNEUROSCI.1395-19.2019

Figure 7.

Figure 7.

GAT-1-regulated ambient GABA acts on GABABR to decrease glutamatergic transmission in the NAc core. A, B, Representative experiment and traces of eEPSCs obtained from D1(+) MSNs (blue circles) and D1(−) MSNs (open circles) in the NAc core. Scale bar, 200 pA/50 ms. C, Time course of normalized eEPSC amplitude from D1(+) and D1(−) MSNs in the presence of GABA reuptake (GAT-1) inhibitor, tiagabine (30 μm). D, Time course of normalized eEPSC amplitude from D1(+)and D1(−) MSNs in the presence of tiagabine + SCH 50911 (5 μm). E, Time course of normalized eEPSC amplitude from D1(+) and D1(−) MSNs in the presence of tiagabine (30 μm) and GABABR-PAM, CGP 7930 (30 μm). F, Quantification of average eEPSC amplitude (t = 55–60 min) of tiagabine in normal ACSF, CGP 7930, and SCH 50911 at D1(+)and D1(−) MSNs. Error bars indicate SEM. *p < 0.05.