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Summary of in vivo TraDIS screening results. (A and B) An overall fitness factor was determined for each gene as described in the text. The regions of the essential genes for the mammalian model and the avian model are shown. (C to E) Classification of essential genes. The number of shared virulence-essential genes necessary for systemic infection of both mammalian and avian models (C), mammalian models (D), and avian models (E) in each Gene Ontology functional category.
