FIG 5.
Type I and II interferon signaling enhances the generation of B1 B cell plasmablasts and their production of GM-CSF during malaria infection. Indicated knockout or WT mice (all B6 background) received 2 × 105 P. yoelii 17XNL-infected iRBCs, and 7.5 days later, spleens were harvested and stained for cell surface CD45, CD19, IgM, IgD, and CD43 and intracellular GM-CSF. (A) Representative FACS dot plots across 2 to 3 independent replicate experiments are shown. (B and C) The average result across all experiments is shown, with each dot representing an individual mouse (n = 4 to 19 for knockout [KO] mice, n = 44 for WT mice).