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Reduced VIM20 and oxidized VIM20 feature overall similar structures, with differences localized to the active site. (A) An overlay of oxidized VIM-20 (OxVIM-20, pink) and reduced VIM-20 (RedVIM-20, light blue) highlights key differences. (B) The structure of RedVIM-20 features two zinc ions and a reduced Cys198 sulfhydryl. (C) The structure of OxVIM-20 features a single zinc ion and Cys198 oxidized to a sulfonic acid.
