TABLE 1.

Summary of MIC values for select VIM variants^a

Drug(s)b	MIC (μg/ml) for E. coli DH10B/pBC variant (mutation):
	SK(-)	SK(-) blaVIM-2	SK(-) blaVIM-20 (H229R)	SK(-) blaVIM-4	SK(-) blaVIM-28 (H201L)	SK(-) blaVIM-37 (A58S)	SK(-) blaVIM-1	SK(-) blaVIM-59 (H229R)	All others (range)
AMP	4	1,024	1,024	8,192	8,192	8,192	8,192	8,192	32–8,192
AMP + EDTA	4	16	256	64	1,024	512	128	512	4–512
CAZ	0.5	32	32	64	128	32	1,024	1,024	2–1,024
CAZ + EDTA	0.5	1	8	1	16	2	32	128	0.25–128
CF	4	256	512	1,024	1,024	1,024	2,048	2,048	32–2,048
CF + EDTA	4	16	128	32	256	128	64	256	4–256
IMI	0.25	4	8	8	16	16	8	8	0.5–16
IMI + EDTA	0.25	0.25	0.5	0.25	1	1	0.5	1	0.25–1
MER	0.03	0.5	0.5	1	2	4	1	1	0.125–4
MER + EDTA	0.015	0.03	0.125	0.03	0.25	0.125	0.06	0.25	0.03–0.25
ERT	0.015	0.25	0.5	1	4	4	1	1	0.015–8
ERT + EDTA	0.0075	0.015	0.06	0.015	0.5	0.25	0.015	0.125	0.015–0.25

^aSee Tables S1 to S3 for more details.

^bAMP, ampicillin; CAZ, ceftazidime; CF, cephalothin; IMI, imipenem; MER, meropenem; ERT, ertapenem.