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. 2019 Nov 21;2019(11):CD011931. doi: 10.1002/14651858.CD011931.pub2

Choi 2009.

Methods Study design: randomized controlled trial (2 arms)
Study duration: not reported
Study setting: hospital, single centre, China
Participants Adults undergoing elective craniotomy (n = 32)
Inclusion criteria
  1. Adults undergoing elective craniotomy


Exclusion criteria
  1. Inability to understand the pain scoring system

  2. Allergy to study drugs


Mean age, range (years)
  1. 44 (18 to 70)


Numbers allocated to each arm
  1. Group intervention (n = 16)

  2. Group control (n = 16)


Male gender
  1. Group intervention: 5/16

  2. Group control: 4/16

Interventions Technique and timing
Scalp block of the following nerves:
  1. Supraorbital and supratrochlear

  2. Zygomaticotemporal

  3. Auriculotemporal

  4. Postauricular branches of the greater auricular

  5. Greater, lesser, and third occipital nerves


with 0.75% ropivacaine versus scalp block with saline, at the end of surgery
Dosage
2 to 3 mL per nerve
Outcomes Primary
  1. Pain as measured by the VAS (0 to 100 mm) during the first 48 hours postoperatively (at 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours and 48 hours)


Secondary
  1. Time to requirement of rescue analgesia

  2. Total amount of rescue analgesia required

  3. Heart rate and blood pressure

Notes Published in Chinese only
  1. Paper published in Chinese only, translator used but translation errors possible


Funding
None
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk A computer‐generated randomization table was used.
Allocation concealment (selection bias) High risk Not reported
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not reported
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not reported
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No losses to follow‐up. All participants were included in the final analysis.
Selective reporting (reporting bias) Low risk Outcomes reported as specified
Other bias Unclear risk Small study