FIGURE 2.

Summary of the function of insulin signaling in metabolic organs and LECs. Insulin signaling in the liver promotes glycogen, lipid, and protein synthesis while decreases glucose production. In the skeletal muscle, insulin mediates glucose uptake and glycogen synthesis. In white adipose tissue, insulin suppresses lipolysis and promotes glucose uptake. Insulin activation of its receptor in LECs promotes eNOS activity, which keeps normal lymphatic structure, and promotes lymphangiogenesis. WAT, white adipose tissue; LEC, lymphatic endothelial cell; eNOS, endothelial nitric oxide synthase.