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. 2019 Nov 14;9:1247. doi: 10.3389/fonc.2019.01247

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Copyright © 2019 Qin, Li, Li, Zhang, Tian, Shang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The detailed expression of TFEB. Representative images of TFEB protein expression in liver cancer's corresponding (A) non-cancerous (NC) and (B) cancerous (C) regions. (C) Quantification of TFEB expression (total, cytoplasmic, and nuclear expressions and the rate of nuclear localization) levels using multispectral image analysis in the liver cancer samples. (D) The ratio of “cancerous region/non-cancerous region” of TFEB expression in two groups (well-differentiated group vs. moderately and poorly differentiated group). The red line indicates that the ratio is equal to 1. Scale bar: 200 or 50 μm. **Denotes significant differences from the well-differentiated group with P < 0.01; ***Denotes significant differences from the noncancerous region with P < 0.001.