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. 2019 Nov 14;7:279. doi: 10.3389/fcell.2019.00279

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Copyright © 2019 Lawrimore, Doshi, Walker and Bloom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Default kinetochore model organization. (A) Cartoon of the kinetochore model. The model is oriented end-on from the spindle, so the sister kinetochore complexes and SPBs (red dots) overlay each other. Cse4s (green dots) are located on the central axis of the microtubule. The N-termini of Nuf2 are blue dots (Joglekar et al., 2009) that bind the plus-end of the simulated kinetochore microtubules (kMTs), which are not shown. SPBs (red dots) are represented in our model as fluorophores surrounding the minus ends of the kMTs. (B) Side-view of the volumetric model, generated by the Microscope Simulator 2 program, of the organization that will be used for simulated, fluorescent image generation. (C) The simulated microscope image of the organization shown in panel (B).