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. 2019 Nov 20;9:186. doi: 10.1186/s13568-019-0912-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Putative metabolic pathway for the bioproduction of bikaverin 1 and intermediates thereof in F. oxysporum LCP531 based on both the identified compounds profiles produced in either intracellular or extracellular extracts and the previously reported model for bikaverin biosynthesis in F. fujikuroi (Arndt et al. 2015; Caspi et al. 2018). Numbers are referring to the compounds characterized in Figs. 2 and 3, and colors correspond to the shades of the pigments isolated in this study. Major pigments are highlighted in bold (bikaverin 1, norbikaverin 2, oxo-pre-bikaverin 3, me-oxo-pre-bikaverin 4, dinor-bikaverin 5, and pre-bikaverin 6). Pre-bikaverin was first described by Ma et al. (2007)