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. 2019 Nov 14;10:1204. doi: 10.3389/fneur.2019.01204

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Copyright © 2019 Trošt, Perovnik and Pirtošek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Parkinson's disease-related cognitive pattern (PDCP) identified by scaled subprofile model/principal component analysis (SSM/PCA) from a group of 15 non-demented PD patients. PDCP is characterized by bilateral hypometabolism in the supplementary motor area (preSMA), precuneus, the dorsal premotor cortex (PMC), inferior parietal lobule and left prefrontal region and relative increases in the cerebellar vermis and dentate nuclei (DN). Voxels showing metabolic increases are color-coded red and those showing metabolic decreases are color-coded blue. Reprinted with permission from Huang et al. (101).