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. 2019 Nov 20;9:17178. doi: 10.1038/s41598-019-52841-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression heatmap. Hierarchical clustering with Pearson’s correlation similarity and average linkage. Heatmap showing the 1466 genes associated with prognosis in the meta-analysis of Cox models (FDR < 0.05). We perceive four main clusters (I-IV). In addition to favorable (a) and unfavorable (c) patient groups, there seems to be an intermediate group (b), characterized by a distinct pattern of low expression in cluster I and III and high expression in clusters II and IV. Chromosome 3 loss, class 2 tumors and relapse before 3 years of follow-up are shown in black.