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. 2019 Nov 20;9:17178. doi: 10.1038/s41598-019-52841-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The risk score was specifically associated with liver relapse in colorectal cancer. Log hazard ratio estimates with standard error bars are shown horizontally for both datasets (upper part) and the meta-analysis (RE model, bottom part). The lack of association is at zero (dotted vertical line). In a meta-analysis (RE model) of (A) univariable and (B) bivariable logistic regression, the risk score was consistently and significantly associated with liver relapse, even after adjustment for CMS groups. Data from PETACC-3 and GSE14095. (C) In the prospective PETACC data, the proportion of total relapse was similar in CMS1-3, as expected. Liver relapse was lower in CMS1.