Table 2.
Genes associated with relapse in uveal melanoma.
| Gene | HR | 95% CI | FDR | Location |
|---|---|---|---|---|
| JPH1 | 2.00 | (1.56 to 2.57) | <0.001 | 8q21.11 |
| PTP4A3 | 2.13 | (1.62 to 2.80) | <0.001 | 8q24.3 |
| ID2 | 0.56 | (0.44 to 0.70) | 0.002 | 2p25.1 |
| POP1 | 1.68 | (1.37 to 2.06) | 0.002 | 8q22.2 |
| CYP4X1 | 1.62 | (1.33 to 1.97) | 0.004 | 1p33 |
| HPN | 1.65 | (1.33 to 2.05) | 0.009 | 19q13.11 |
| FYN | 0.61 | (0.50 to 0.75) | 0.009 | 6q21 |
| LPIN1 | 0.58 | (0.46 to 0.73) | 0.009 | 2p25.1 |
| ETNPPL | 1.69 | (1.34 to 2.12) | 0.011 | 4q25 |
| MARC2 | 0.63 | (0.52 to 0.78) | 0.012 | 1q41 |
| TLCD1 | 1.68 | (1.33 to 2.10) | 0.012 | 17q11.2 |
| TSC22D1 | 1.61 | (1.30 to 1.99) | 0.013 | 13q14.11 |
| VCPIP1 | 1.69 | (1.33 to 2.15) | 0.014 | 8q13.1 |
| ANG | 0.52 | (0.39 to 0.70) | 0.014 | 14q11.2 |
| RAB11FIP1 | 0.62 | (0.50 to 0.77) | 0.014 | 8p11.23 |
| DNAAF3 | 0.56 | (0.43 to 0.73) | 0.014 | 19q13.42 |
| GALM | 0.67 | (0.55 to 0.80) | 0.014 | 2p22.1 |
| ASAP1 | 1.70 | (1.33 to 2.17) | 0.015 | 8q24.22 |
| CBS | 1.48 | (1.23 to 1.77) | 0.016 | 21q22.3 |
| MTFR1 | 1.61 | (1.29 to 2.01) | 0.018 | 8q13.1 |
Top 20 genes by lowest FDR shown (full results in the supplement) in a meta-analysis of bivariable survival models including chromosome 3 and the expression of each individual gene.