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. 2019 Nov 20;9:17208. doi: 10.1038/s41598-019-53356-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent plasma concentrations of Exenatide following a single subcutaneous dose of PT320 (0.44 or 1.1 mg/kg) or Bydureon (1.1 mg/kg) to nonhuman primates. (A) Classical semi-log plot of plasma Exenatide levels by treatment group from 30 min to 84 days (0.5 to 2016 hr). (B) Linear. Plot of the same data to emphasize the different times that steady-state Exenatide levels were achieved following administration of either PT320 (blue and orange lines) vs. Bydureon (gray). (C) Plot of AUC values at the times noted in (A and B). Values are means ± SEM, *p < 0.05.