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Anti-Exenatide antibodies evaluated in plasma at 6 and 12 weeks post subcutaneous Exenatide administration in the form of either PT320 (0.44 or 1.1 mg/kg) or Bydureon (1.1 mg/kg) to nonhuman primates. (+): positive antibody titer; (−): no antibody titer.
| Nonhuman primate | Anti-Exenatide antibody (1:25) | |
|---|---|---|
| 6 weeks | 12 weeks | |
| # 1 | (−) | (−) |
| # 2 | (−) | (−) |
| # 3 | (−) | (−) |
| # 4 | (+) | (+) |
| # 5 | (−) | (−) |
| # 6 | (−) | (−) |
| # 7 | (−) | (−) |
| # 8 | (−) | (−) |
| # 9 | (−) | (−) |
| # 10 | (−) | (−) |
| # 11 | (−) | (−) |
| # 12 | (+) | (+) |
