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. 2019 Nov 20;10:5262. doi: 10.1038/s41467-019-13238-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — SB modified alginates mitigate FBR in dogs and pigs. a A laparoscopic image during retrieval of SB-SLG20 alginate microcapsules, 45 days after intraperitoneal implantation in a dog. b A laparoscopic image during retrieval of SLG20 control microcapsules. c A phase contrast image of retrieved SB-SLG20 microcapsules (n = 3; scale bar, 2 mm; see Supplementary Fig. 28 for complete data). d Retrieved SB-SLG20 microcapsules in a Petri dish. e H&E stained cross-sectional image of retrieved SB-SLG20 microcapsules (Scale bar, 500 μm). f A phase contrast image of retrieved SLG20 microcapsules (n = 1; scale bar, 2 mm). g H&E stained cross-sectional image of retrieved SLG20 microcapsules (Scale bar, 500 μm). h A laparoscopic image during retrieval of SB-SLG20 alginate microcapsules, 90 days after intraperitoneal implantation in a dog. i A phase contrast image of retrieved SB-SLG20 microcapsules (n = 2; scale bar, 2 mm; see Supplementary Fig. 29 for complete data). j H&E stained cross-sectional image of retrieved SB-SLG20 microcapsules (Scale bar, 500 μm). k Representative Masson’s trichrome staining (and a higher magnification) images of retrieved SLG100 alginate microcapsules (n = 2; scale bar, 500 μm), 1 month after implantation into the pig omental bursa. l Representative Masson’s trichrome (and a higher magnification) staining images of retrieved SB-SLG100 alginate microcapsules (n = 2; scale bar, 500 μm). m PAS-stained histology (and a higher magnification; scale bar, 200 μm) images of retrieved SLG100 microcapsules (Scale bar, 1 mm). Arrow indicates foreign body giant cells. n PAS-stained histology (and a higher magnification; scale bar, 200 μm) images of retrieved SB-SLG100 microcapsules (scale bar, 1 mm)