Fig. 5.

SB-SLG20 microcapsules improve diabetes correction in mice in a 90-day study. a A dark-field phase contrast image of SLG20 microcapsules encapsulating rat islets before transplantation. Scale bar, 1 mm. b Blood glucose concentrations of mice (n = 6 per treatment group). c Intraperitoneal glucose tolerance test (IPGTT) before retrieval (n = 3). d Ex vivo glucose-stimulated insulin secretion (GSIS) of retrieved islet-containing SB-SLG20 microcapsules, n = 3, Mean ± SEM, *P < 0.05. e A dark-field phase contrast image of retrieved islet-containing SB-SLG20 microcapsules (n = 6; see Supplementary Fig. 35 for complete data. Scale bars, 2 mm on the left and 1 mm on the right). f An H&E stained cross-sectional image of retrieved islet-containing SB-SLG20 microcapsules. Scale bar, 500 μm. g Immunohistochemical staining of a rat islet in a retrieved SB-SLG20 microcapsule. Insulin is stained red and nuclei are stained blue (Scale bar, 50 μm). h, i Dark-field phase contrast images of retrieved islet-containing SLG20 microcapsules from the normoglycemic mouse group (h) and failed ones (i). (n = 6; scale bar = 2 mm; see Supplementary Fig. 37 for complete data). j An H&E stained cross-sectional image of retrieved islet-containing SLG20 microcapsule (Scale bar, 200 μm)