Fig. 6.

SB-SLG20 microcapsules improve diabetes correction in mice in a 200-day study. a Blood glucose concentrations of mice (n = 6 mice per treatment group). b Intraperitoneal glucose tolerance test (IPGTT) before retrieval (n = 3). c Ex vivo GSIS of the retrieved rat islets from SB-SLG20 microcapsules, n = 3, Mean ± SEM, *P < 0.05. d A dark-field phase contrast image of retrieved islet-containing SB-SLG20 microcapsules. (n = 6; scale bar, 2 mm; see Supplementary Fig. 38 for complete data). e An H&E stained cross-sectional image of retrieved islet-containing SB-SLG20 microcapsules. Scale bar, 500 μm. f Immunohistochemical staining of rat islets in retrieved SB-SLG20 microcapsules. Insulin is stained red and nuclei are stained blue (Scale bar: 50 μm). g A dark-field phase contrast image of retrieved islet-containing SLG20 microcapsules. (n = 6; scale bar, 2 mm; see Supplementary Fig. 40 for complete data). h An H&E stained cross-sectional image of retrieved islet-containing SLG20 microcapsules. Scale bar, 500 μm. i Immunohistochemical staining of rat islets in retrieved SLG20 microcapsules. Insulin staining is negative and nuclei are stained blue. Scale bar, 500 μm