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. 2019 Nov 20;9:17172. doi: 10.1038/s41598-019-53645-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Levels of soluble markers in plasma samples from NI blood donors (Control) (black) and from DENV (blue)-, WNV (orange)- and ZIKV (gray)-infected blood donors. Data are displayed in Log₁₀ scale as median with interquartile range of plasma concentration (pg/mL) for each marker. Boxes, median values and interquartile range; whiskers, 10–90 percentile; Points below and above the whiskers are drawn as individual points. Statistical significance was considered at p < 0.05 and is represented by lines and with * for P < 0.05, ** for P < 0.01, and *** for P < 0.001, **** for P < 0.0001.