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. 2019 Nov 20;9:17172. doi: 10.1038/s41598-019-53645-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overall marker signature of soluble markers in plasma samples from DENV-, WNV- or ZIKV-infected blood donors and NI blood donors. (a) The marker signatures were assembled as an ascendant curve showing the frequency of individuals with plasma marker levels above the global median for each group. Markers with expression greater than the global median in more than 50% of the individuals are highlighted in gray. (b) A Venn diagram was built to characterize the overall frequency pattern of highly-expressed markers in each group. Venn diagram table lists the selected markers that were highly induced in each group.