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. 2019 Nov 20;9:17158. doi: 10.1038/s41598-019-53466-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PGC-1α protein levels are increased and TFAM and DNM1L protein levels are decreased in brain lysates from wt and gp120-tg mice administered Tenofovir disproxil fumarate. (a) Immunoblot for PGC-1α, TFAM, and DNM1L using whole lysates from hippocampal region. (b—d) Densitometry for quantification of PGC-1α, and TFAM, and DNM1L normalized to total protein levels. Significance (p < 0.05) was determined by two-way ANOVA (wt, n = 8; wt + TDF, n = 5; gp120-tg, n = 7; gp120-tg, n = 7).