Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 20;9:17158. doi: 10.1038/s41598-019-53466-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Tenofovir disproxil fumarate increases GFAP expression, reduces TFAM expression, and increases TFAM colocalization with GFAP in hippocampi of wt and gp120tg mice. Vibratome sections were immunolabelled with antibody against GFAP and then double immunolabelled for TFAM and GFAP. (a) GFAP-DAB immunostaining in hippocampi. (b) Quantification of GFAP corrected optical density. (c) TFAM (red) and GFAP (green) signal in hippocampi. (d–e) Quantified colocalization of TFAM and GFAP and colocalization of TFAM with GFAP (white arrows indicate points of colocalization). Analyzed with two-way ANOVA test (wt, n = 3; wt + TDF, n = 4; gp120-tg, n = 4; gp120-tg, n = 4).