Table 1.
Peripheral neuropathy caused by tenofovir (T).
| Group | N | M:F | Body Weight (g) | Rotarod Latency (sec) | MNCV (m/sec) | Heat Response Threshold (°C) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Onset | Final | Onset | Final | Onset | Final | Onset | Final | |||
| WT + V | 8 | 1:7 | 28.5 ± 1.9 | 27.8 ± 2.0 | 11.1 ± 1.9 | 18.9 ± 3.5a | 43.2 ± 1.4 | 41.1 ± 2.9 | 38.8 ± 0.6 | 38.0 ± 0.7 |
| WT + T | 5 | 2:3 | 31.4 ± 3.7 | 30.8 ± 4.2 | 8.1 ± 0.7 | 17.6 ± 3.4a | 44.1 ± 0.7 | 28.8 ± 5.2a | 39.8 ± 1.0 | 36.0 ± 0.5a |
| gp120-tg + V | 9 | 6:3 | 31.4 ± 2.5 | 30.2 ± 2.5 | 10.4 ± 1.1 | 11.4 ± 3.4 | 42.1 ± 1.8 | 38.9 ± 3.7 | 40.9 ± 1.0 | 39.8 ± 1.3 |
| gp120-tg + T | 12 | 8:4 | 29.6 ± 1.9 | 28.7 ± 2.1 | 9.7 ± 1.1 | 18.2 ± 1.8c | 43.7 ± 2.0 | 32.7 ± 3.2c | 40.2 ± 0.6 | 37.7 ± 0.7b |
Mice were 7–8 months old at the start of the study and tenofovir was given daily (50 mg/kg po) for 4 weeks. Data are group mean ± SEM. a,b,cp < 0.05, p < 0.01 and p < 0.001 vs group onset values by paired t test.