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. 2019 Nov 20;9:17195. doi: 10.1038/s41598-019-53900-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fetal and adult reproductive structures are overtly normal in Adamts16-deficient mice. (A–C) At 16.5 dpc, the fetal testes (t) have descended to a position adjacent to the bladder in wild-type (B) and Adamts16 −/− mutant males (C); this is in contrast to the para-renal position of the ovaries (o) in wild-type females at the same stage (A). Scale bar = 0.5 mm; (D,E) Testes in adult mice have descended in to the scrotum in wild-type (D) and Adamts16 −/− mutant males (E); scale bar = 0.5 cm; (F) The average weight of the adult testis is reduced in the Adamts16 −/− mutant males (n = 28) compared to wild-type controls (n = 24); ***p ≤ 0.01 (student’s t-test); (G,H) Testicular histology of H&E-stained section appears unaltered in mutant males (H) when compared to wild-type controls (G). Scale bar = 100 μm.