Table 2.
Therapeutic effects on the lung bacterial loads at 24 and 48 h after starting the antibiotic agents.
| Antibiotic regimen | 24 h | 48 h |
|---|---|---|
| Control | 12.24 ± 0.44 | 12.99 ± 0.22 |
| COL | 9.65 ± 0.43a | 8.73 ± 0.34a |
| FOS | 7.68 ± 0.47a | 6.68 ± 1.02a |
| MIN | 9.26 ± 0.19a | 7.73 ± 1.33a |
| COL + FOS | 5.63 ± 0.26a,b | 3.46 ± 0.42a,b,c |
| COL + MIN | 6.07 ± 1.04a,b | 5.16 ± 0.83a,b |
COL, colistin; MIN, minocycline; FOS, fosfomycin.
The lung bacterial loads are expressed as the mean ± standard deviation of log10 CFU per gram of lung at 24 and 48 h.
aSignificant difference in bacterial load compared with the control group (p < 0.05).
bSignificant difference in bacterial load compared with the more active antibiotic alone (p < 0.05).
cSignificant difference in bacterial load compared with the other combination (p < 0.05).