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. 2019 Nov 20;9:17180. doi: 10.1038/s41598-019-53562-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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C57BL/6 mice undergoing splenic irradiation with a multi-fraction regimen of 1 Gy per day for 5 days or a single fraction of 5 Gy experience severe lymphopenia irrespective of dose rate. (a–d) Flow cytometric CD3, CD4, CD8, and CD19 counts in the peripheral blood of mice on day 3 following conventional or ultra-high dose rate RT with the multi-fraction regimen. (e–h) Flow cytometric CD3, CD4, CD8, and CD19 counts in the peripheral blood of mice on day 3 following conventional or ultra-high dose rate RT with a single fraction of 5 Gy. Data are the mean percentages of cells ± SE. *p < 0.05 compared between control and other cohorts. Data are derived from experiment conducted in triplicates. (n = 5 in control, high dose rate and conventional dose rate group).