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. 2019 Nov 20;9:17213. doi: 10.1038/s41598-019-53610-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NP23-NHD13 mice develop aggressive AML. (a) Structure of NUP98 (top), NUP98-PHF23 fusion transgene (middle), and NUP98-HOXD13 fusion transgene (bottom). Protein fusion points are indicated by arrow; Vav regulatory elements are indicated in yellow. (b) Survival of NP23-NHD13(n = 11), NP23(n = 22), NHD13(n = 9) and WT(n = 17) mice. WT and NHD13 curves are superimposed at 100% survival each. Data analyzed by Log-rank (Mantel-Cox) test, ^****P < 0.0001 (WT vs NP23-NHD13). (c) Thymus is more heavily invaded with Mac1+/Gr1 + leukemic cells than BM in several samples. (d) Tissue invasion of myeloid cells. Data are expressed as means ± SD, n = 9 mice. (e) Sheets of myeloblasts in peripheral blood smear; several examples indicated with red arrows. (f) H&E staining of leukemic cell invasion in parenchymal organs (spleen, liver and thymus); myeloperoxidase (MPO) staining of infiltrate. ns = not significant, *P < 0.05, ****P < 0.0001, by one-way ANOVA with a correction provided by the Tukey’s multiple comparisons test. Scale bars = 200 μm for blasts count, 800 μm (low power view), 50 μm (high power view).