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. 2019 Nov 20;9:17213. doi: 10.1038/s41598-019-53610-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DN1 and DN2 thymocytes from NP23-NHD13 mice transmit AML. (a) Sorting strategy for purification of DN populations. The entire sorted population was transplanted (DN1 = 8.7 × 10³/recipient, DN2 = 3.7 × 10⁴/recipient, DN3 = 5 × 10³/recipient, DN4 = 2.4 × 10⁴/recipient, WT-DN = 10⁵cells/recipient), n = 4–5 mice per group. (b) Survival curve shows DN1 and DN2 recipients develop disease. Data analyzed by Log-rank (Mantel-Cox) test. (c,d) Biphasic engraftment pattern of donor cells (CD45.2) is shown in both DN1 and DN2 recipients, (dotted circle indicates engraftment data obtained from BM). (e) Flow cytometry of transplant recipient mice from DN1 and (f) DN2 recipients demonstrate engraftment of donor derived AML cells. *P < 0.05.