Table 1.
Clinical characteristics at hospital admission (V1).
| Clinical characteristics | |
|---|---|
| Number of PEx | 25 |
| Number of subjects | 22 |
| Age, mean (SD) | 34.8 (12.9) |
| Female, No. (%) | 12 (48) |
| Genotype, No. (%) | |
| ΔF508 Homozygous | 11 (50) |
| F508 Heterozygous | 7 (32) |
| Other (non-F508) | 4 (18) |
| FEV1% predicted, mean (SD) | 53.2 (20.7) |
| >10% relative drop FEV1% predicted from baseline, No. (%)a | 14 (56) |
| BMI, mean (SD) | 21.7 (3.5) |
| CFRSD-CRISS, mean (SD) | 50.5 (7.5) |
| Modified Fuchs Score, median (range) | 6 (4 to 8) |
| Best FEV1% predicted in 6 months prior to PEx, mean (SD) | 63.4 (21.5) |
| Best FEV1% predicted in 6 months prior to PEx, No. (%) | |
| <40 | 4 (16) |
| 40–69 | 11 (44) |
| 70–89 | 4 (16) |
| ≥90 | 6 (24) |
| Sputum Microbiology, No. (%) | |
| P. aeruginosa | 14 (56) |
| MSSA | 12 (48) |
| MRSA | 4 (16) |
| Burkholderia cepacia complex | 3 (12) |
| Symptom Onset, No. (%) | |
| >2 weeks | 13 (52) |
| <2 weeks | 12 (48) |
Abbreviation: PEx, pulmonary exacerbations; FEV1, forced expiratory volume in 1 second; BMI, body mass index; CFRSD-CRISS, CF Respiratory Symptom Diary-Chronic Respiratory Infection Symptom Score; P. aeruginosa, Pseudomonas aeruginosa; MSSA, Methicillin-sensitive S. aureus; MRSA, Methicillin-resistant S. aureus.
aBaseline lung function is defined as the best FEV1% predicted in the 6 months prior to the index PEx.