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. 2019 Nov 20;10:5234. doi: 10.1038/s41467-019-13144-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Validation of the PD MEGENA network by Stmn2 perturbation. a Volcano plot shows genes that are significantly differentially expressed in the midbrain between the mice received scrambled AAV and Stmn2-shRNA AAV. b The genes in M4 are significantly enriched for the downregulated DEGs identified in the midbrain of the Stmn2 knockdown mice. Nodes with burgundy labels are key hubs of M4. The left-side half circle of each node indicates the DEGs in human between the PD and control groups while the right-side represents the DEGs in mice by Stmn2 knockdown. c The two-layer network neighborhood of STMN2 is significantly enriched for the DEG downregulated by Stmn2 knockdown. Nodes with burgundy labels are key hubs in the MEGENA network. The left upper part of the circle represents the DEG in human between the PD and control groups while the right upper part of the circle represents the correlation with STMN2 in PD patients. The bottom part of the circle indicates the DEGs in mice by Stmn2 knockdown