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. 2019 Nov 20;10:5247. doi: 10.1038/s41467-019-13234-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Public features of clonotypes with more than one isolate from our dataset. a A heat map illustrating 9 groups (I–IX) of cells from multiple subjects sharing identical paired TRBJ/TRAJ genes. Number of isolates of the same clonotype is proportional to the color intensity. Tetramer specificity is differentiated by colors. Tetramer categories without any hit on the heat map are not shown. b Frequencies of V or J genes used in 57 TCRα/β clonotypes with multiple isolates compared with “All Wells” that return sequences (see Supplementary Data 2) or “All Cells” with productive α/β CDR3 sequences (see Supplementary Data 3). Arrows indicate genes used in TRBV29–1_TRBJ2-5/TRAV6_TRAJ24-expressing cells, with fold increase compared to “All Cells”