. Author manuscript; available in PMC: 2020 Dec 7.

Published in final edited form as: Soft Matter. 2019 Oct 31;15(45):9271–9286. doi: 10.1039/c9sm01653h

Table 1.

Binding of NPs to diffusing ICAM-1 receptors on the cell surface: model validation

NP/membrane type	Methods	Findings and citation
Rigid/rigid	MC/in vivo, in vitro, AFM	Enhanced binding at large ligand surface coverage.³⁴
Rigid/rigid	MC/in vivo	Increased selectivity using controlled reduction of receptor surface density.³⁵
Rigid/flexible	MC/in vivo	Binding kinetics are influenced by mechanotype & phenotype of target cells.³⁶
Flexible/—	CGMD/in vitro	1. Computed stiffness of the NP falls in the range of moderately soft materials. 2. Model 5 in the computation best represents the properties of the polymeric NP utilized in the experiments.³⁷
Flexible/rigid	CGMD & MC/in vivo, in vitro	Shear-enhanced binding, effects of RBC volume fraction and NP stiffness.^19,20