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. Author manuscript; available in PMC: 2020 Nov 20.
Published in final edited form as: Bioconjug Chem. 2019 Oct 22;30(11):2947–2957. doi: 10.1021/acs.bioconjchem.9b00640

Figure 6. ND-ProGlo demonstrates significantly increased delivery of CA:

Figure 6.

The CA delivery is significantly increased to PR-rich reproductive tissues (uterus and ovaries) over untargeted controls (ND-C5-COOH) at 6 (a) and 24 (b) hours. At both times, the biodistribution of ND-ProGlo (ND-PG) appears consistent with that of ProGlo, indicating that ProGlo is released effectively after injection of ND-PG. Conversely, the control complex, ND-C5-COOH, is cleared rapidly through the kidneys with little remaining at 24 hours.