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. Author manuscript; available in PMC: 2020 Nov 20.
Published in final edited form as: Bioconjug Chem. 2019 Oct 22;30(11):2947–2957. doi: 10.1021/acs.bioconjchem.9b00640

Scheme 1. ND’s are used for the controlled release of the PR-targeted MR contrast agents.

Scheme 1.

The molecular contrast agents require DMSO to solubilize the material in solution. When the agent is coordinated to the ND’s they do not require DMSO or other solvents for delivery. This result is highly significant for in vivo studies.