Figure 7.

Abundance and asymmetry of predicted CEs with overlaps of motifs and with spacers. Abundance of heterotypic CEs with overlaps of motifs (A) and those with spacers of length below 30 bp (B) as a function of the CE significance (axes X) and the significance of asymmetry in conservation between anchor and partner motifs (axes Y), see Materials and Methods. The color keys show the CE abundance for 117/47 human/mouse ChIP-seq datasets (see Supplementary Table S1). CEs consisted of an anchor motif and either of 396/353 partner motifs from the Hocomoco human/mouse libraries (30), see Materials and Methods. CEs without the significant match of anchor and partner motifs (P-value > 0.05) were kept in analysis. This figure shows that predicted CEs with overlaps compared to those with spacers are more abundant and more often comprise two motifs of various conservation.